For years it has been the aim of research investigators to find a procedure by which cataract might be developed experimentally in laboratory animals. This achievement they believed would create a better understanding of the changes observed in the ocular tissue of man leading to the formation of mature cataract. The contributions to this subject have been legion and the interpretation of the observations just as numerous. Notwithstanding all the accumulated literature and clinical and laboratory data, the causative factors of cataract formation remain an enigma.
It is known that lenticular changes may be present at birth or have their inception at puberty, progress at 40 and develop at 60, but not all elderly persons have mature cataracts. The incidence of cataract is great enough to warrant further investigation of the subject. It is conceded that no single factor is responsible for cataract formation in man. The present remedial methods
YUDKIN AM, GEER HA. AN INVESTIGATION OF EXPERIMENTAL CATARACTS IN THE ALBINO RAT: CLINICAL IMPLICATIONS. Arch Ophthalmol. 1940;23(1):28–40. doi:10.1001/archopht.1940.00860130040003
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