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Article
May 1940

PRIMARY TUMORS OF THE OPTIC NERVE (A PHENOMENON OF RECKLINGHAUSEN'S DISEASE): A CLINICAL AND PATHOLOGIC STUDY WITH A REPORT OF FIVE CASES AND A REVIEW OF THE LITERATURE

Author Affiliations

MADISON, WIS.

Arch Ophthalmol. 1940;23(5):957-1022. doi:10.1001/archopht.1940.00860131081007
Abstract

GENERAL COMMENT 

Nature of Gliomas as Revealed by This Study.  —It is evident from a comparison of sections of the tumors removed from patients in cases 1, 2 and 3 (figs. 14, 23 and 56) that they are essentially the same process, though careful study reveals considerable variation, especially in that part of the tumor which involves the sheath.When viewed as a group, certain histologie details stand out which suggest five different stages in the evolution of these growths.At stage 1 there is a generalized hyperplasia of the neuroglia within the nerve stem, with early fiber formation by fibrous astrocytes. The glial cells, both astrocytes and oligodendrocytes, have started to proliferate in an abnormal manner from some unknown cause. The first operative specimen in case 3 illustrates this stage (figs. 39, 40 and 41). The cases reported by Bailey and Herrmann (cited on page 984) and Aegerter and

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