The use of solid carbon dioxide in medicine is not new. This preparation was first employed by dermatologists for the removal of moles, warts, small epitheliomas, angiomas and nevi and for the treatment of xanthelasma, molluscum contagiosum and some diseases of the mouth and uterus.
Later its use was extended to the treatment of diseases of the eye, such as follicular conjunctivitis, lymphatic hypertrophy of the fornices, trachoma and vernal catarrh, but it never became popular, not on account of the results, which were found to be fairly satisfactory by all authors, but principally because the applications required a tedious preparation of the solid carbon dioxide from a tank containing the gas. Lately, as the commercial use of solid carbon dioxide has been extended for freezing purposes, it can easily be found in any candy shop; in the New York area it is distributed under the name of dry ice.
LA ROCCA V. TREATMENT OF VERNAL CATARRH WITH SOLID CARBON DIOXIDE. Arch Ophthalmol. 1940;23(5):1039–1045. doi:10.1001/archopht.1940.00860131163009
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