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To the Editor:
—The loss of the response of the pupil to physostigmine salicylate does not develop immediately after severance of the oculomotor nerve but within a few days after the operation. As pointed out by Sollmann (A Manual of Pharmacology, ed. 5, Philadelphia, W. B. Saunders Company, 1936, p. 345), it seems that the loss of the miotic response is related to the development of degenerative changes, which requires a certain time. In our experiment the section of the oculomotor nerve and the instillation of physostigmine salicylate were made on the same day, as shown by the protocol (page 373), so that a reaction to the
E. Spiegel. PUPILLARY RESPONSE TO PHYSOSTIGMINE SALICYLATE IN ABSENCE OF OCULOMOTOR NERVE. Arch Ophthalmol. 1940;23(5):1090. doi:10.1001/archopht.1940.00860131218015