Twenty-one cases of retinitis pigmentosa in which the familial history and certain physical characteristics were studied form the basis of this report. Because of the well known effect of the pituitary gland (pars intermedia) on the pigmentary system, it was felt that some clinical characteristics might be present which would link this gland with retinitis pigmentosa. Furthermore, owing to certain clinical findings, the embryologic development of the hypothalamic-pituitary and optic systems was thought to be of importance as giving a clue to the causation of this disease.
Involvement of the pituitary gland and the diencephalon in an etiologic role has been thought of by several investigators (Mamola and Bellina,1 Schupfer,2 Viallefont3 and others).
The essential features pertinent to the discussion are given in the accompanying table.
The ages of the patients ranged from 8 to 51 years, the average age being 32.2 years.
There were 11 males
MOEHLIG RC, PINO RH. RETINITIS PIGMENTOSA: ETIOLOGIC AND CLINICAL IMPLICATIONS BASED ON TWENTY-ONE CASES. Arch Ophthalmol. 1940;23(6):1257–1273. doi:10.1001/archopht.1940.00860131417015
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