In previous reports it was suggested that the presence of typhoid H antibodies within the eye, as demonstrated by titrating the aqueous, had an inhibiting effect on the production of experimental iritis. For the sake of convenience, the procedure was designated "interference" therapy.1 This method was employed clinically by injecting varying dilutions of typhoid H antigen intravenously into patients with iritis and uveitis. In conformity with the experimental work, the aqueous was withdrawn by paracentesis of the anterior chamber, and the fresh aqueous richer in antibodies resulted in marked clinical improvement.2 This procedure was also found to inhibit the rate of growth and spread of experimental staphylococcic corneal ulcers in rabbits.
It was thought to be of interest to note the effect of local antibody production in much higher concentration that could be produced by paracentesis after intravenous injection of the antigen. Typhoid H antigen has been used
BROWN AL. EFFECT OF LOCAL TYPHOID H ANTIBODY CONCENTRATION ON PRODUCTION OF CORNEAL ULCERS IN RABBITS. Arch Ophthalmol. 1940;24(1):38–43. doi:10.1001/archopht.1940.00870010060005
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