Data on 100 patients with retrobulbar nueritis, seen in clinic and private practice during a four year period and personally examined and studied by me, form the basis of this report. Not included in the series but observed during the same period were 65 patients with "toxic" amblyopia associated with deficient diets or with the use of tobacco or alcohol. The retrobulbar neuritis of such persons has distinct characteristics and can usually be readily differentiated from the condition which is the subject of this report. Also excluded were persons with toxic amblyopia produced by known toxic agents, such as lead, arsenic and thallium.
In an effort to establish an etiologic diagnosis whenever possible, almost all of the 100 patients were given complete neurologic and medical examinations, including Wassermann tests of the blood, examinations of the spinal fluid, dental and otolaryngologic consultations and roentgenographic examination of the skull, sinuses and teeth
CARROLL FD. RETROBULBAR NEURITIS: OBSERVATIONS ON ONE HUNDRED CASES. Arch Ophthalmol. 1940;24(1):44–54. doi:10.1001/archopht.1940.00870010066006
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