Since Löhr1 (1932) introduced the local application of cod liver oil in the treatment of infected wounds and osteomyelitis, it has been largely used and praised in surgical practice. The results of experimental works on this subject were not so uniformly good as those of clinical observations.
Drigalski2 produced wounds of equal size in the skin of guinea pigs. Those treated with an ointment containing cod liver oil (unguentolan) healed more quickly than those treated with an ointment containing devitaminized cod liver oil. Devitaminized cod liver oil, however, may contain aldehydes and acids of irritating or poisonous action. Lauber and Rocholl,3 on the other hand, attributed the healing property of the locally applied cod liver oil ointment chiefly to the base. They found that an ointment containing concentrated vitamin A, contrary to that of lower concentration, has an inhibitory action on the healing of wounds.
de RÖTTH A. LOCAL ACTION OF OILS CONTAINING VITAMIN AEXPERIMENTAL CONTRIBUTION. Arch Ophthalmol. 1940;24(2):281–291. doi:10.1001/archopht.1940.00870020073008
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