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Article
August 1940

STUDIES IN CONVULSANT THERAPY: IV. THE EFFECTS OF METRAZOL (PENTAMETHYLENETETRAZOL) ON THE EYE

Author Affiliations

NEWTOWN, CONN.
From the Fairfield State Hospital.

Arch Ophthalmol. 1940;24(2):316-325. doi:10.1001/archopht.1940.00870020108010
Abstract

So far-reaching have been the results of metrazol convulsant therapy in recent psychiatric practice that it now seems essential to investigate this interesting drug in its relation to some of the other branches of medicine. The purpose of this report, fourth in a series of studies associated with convulsant therapy, is to compile a detailed record of the effects of metrazol on the human eye. Some of these effects, as seen during the usual course of intravenous injections of metrazol, have already been noted briefly in the literature ; others, especially the local effects resulting from instillation of the drug into the conjunctival sac, are original observations which, as far as known, have not been hitherto described.

In order to examine the ocular phenomena of metrazol in their proper perspective, the reader should know something of the nature of the drug, technic of administration and associated clinical phenomena. These have been

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