Since Jenner first introduced vaccination in 1796, accidental infection of the lids, conjunctivas or corneas has been intermittently reported. Bedell1 could find only 93 cases up to 1920, but since then several have been added, as summarized by Folk and Taube2 in 1933, bringing the total to 99 cases. The infection in only about 25 per cent of these was due to autoinoculation ; that in the remainder was due to contact with persons who had been recently vaccinated against smallpox. The infection in the cases reported by Bedell and by Folk and Taube was of the latter type. Folk and Taube showed experimentally with rabbits that vaccinia blepharitis and conjunctivitis can occur as a result of contact alone of the margins of the lids with the serum from the vaccination pustule. However, in cases of vaccinia of the skin of the lids, more than mere contact is necessary
LAVAL J. VACCINIA OF THE EYES. Arch Ophthalmol. 1940;24(2):367–370. doi:10.1001/archopht.1940.00870020159017
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