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Article
October 1940

VALUE OF TRYPARSAMIDE IN THE TREATMENT OF ATROPHY OF THE OPTIC NERVE DUE TO SYPHILIS

Author Affiliations

LOS ANGELES

Arch Ophthalmol. 1940;24(4):670-680. doi:10.1001/archopht.1940.00870040056004
Abstract

The consideration of amblyopia as it occurs in association with primary atrophy of the optic nerve following tryparsamide therapy is of interest, as within the past two years certain authorities have again advocated the use of this drug for the treatment of neurosyphilis despite the presence of such atrophy. This vacillation in the condemnation and advocacy of a drug is to be expected in view of the fact that tryparsamide is generally conceded to be the most efficacious drug used in the therapy of generalized neurosyphilis, while little is known concerning the mechanism of the production of amblyopia as induced either by syphilis or by the pentavalent arsenical.

Primary atrophy of the optic nerve is probably the most resistant feature of the most resistant form of neurosyphilis, i. e., tabes dorsalis. In earlier days the consensus regarding the value of any form of treatment then extant was pessimistic. When a

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