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Article
October 1940

OCULAR PHARMACOLOGY OF FURFURYL TRIMETHYL AMMONIUM IODIDEWITH SPECIAL REFERENCE TO INTRAOCULAR TENSION

Author Affiliations

BOSTON
From the Division of Psychiatric Research, Boston State Hospital.

Arch Ophthalmol. 1940;24(4):758-760. doi:10.1001/archopht.1940.00870040144011
Abstract

Furfuryl trimethyl ammonium iodide is a new parasympathetic drug, having the following structural formula :

The animal pharmacology was developed by Fellows and Livingston,1 who introduced the drug. They found that the drug is very stable in blood and produces a marked fall in blood pressure, cardiac inhibition and depression, an increased flow of saliva and an increased tone of intestine and bladder. These effects were overcome by atropine.

Myerson, Rinkel, Loman and Dameshek2 have contributed the first paper on its pharmacology in man. The drug is effective by mouth in doses of from 5 to 20 mg. By intramuscular injection, 1 to 5 mg. will produce the full physiologic effects. These are, in general, similar to those produced by acetylbetamethylcholine (mecholyl chloride; mecholyl bromide), although differing in certain important respects. There are marked flushing, sweating and a drop in temperature which is probably the result of the sweating;

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