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Article
November 1940

HEREDITARY PRIMARY GLAUCOMA: A PEDIGREE WITH FIVE GENERATIONS

Arch Ophthalmol. 1940;24(5):885-909. doi:10.1001/archopht.1940.00870050035002
Abstract

Although primary glaucoma is relatively common in its occurrence, it is difficult to state with any degree of certainty how often the disease may be hereditary. In 1906 Nettleship 1 stressed the need for the collection of more data relating to the hereditary nature of glaucoma. Statistics have accumulated slowly, and the evidence is still too vague to justify definite conclusions. A large proportion of the published pedigrees include notes on not more than two generations, and in these only 2 or 3 patients have been studied. Although such records are useful for statistical purposes in respect to sex and age and for the purpose of illustrating certain features of individual case records, they are, unfortunately, of little value in regard to the special study of hereditary factors.

In 1869 von Graefe2 emphasized the importance of inheritance in the etiology of glaucoma and referred to families in which the

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