A report from this laboratory published in the Archives in 1938 1 reviewed the progress to date on the use of galactose as a means of producing experimental cataract in rats. Studies were reported which indicated that rations high in protein were protective and that those low in protein hastened the lenticular changes due to galactose. Yudkin and Geer2 have recently verified the effect of the low protein but questioned the action of the high protein ration. Verification of our previous findings with high protein rations has been followed by further research directed toward the identification of the protective agent. The quest has led into several blind alleys, but finally into one which leads deeper into the nitrogen story. It would appear that some factor in protein or derived from it is responsible for this inhibitory effect even in the presence of the injurious agent, galactose. The present paper
MITCHELL HS, COOK GM, HENDERSON MD. ANTICATARACTOGENIC ACTION OF CERTAIN NITROGENOUS FACTORS. Arch Ophthalmol. 1940;24(5):990–998. doi:10.1001/archopht.1940.00870050140013
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