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Article
December 1940

VASCULAR BASIS OF UVEAL DISEASE: ACUTE ANOXIA AS THE FUNDAMENTAL PATHOLOGIC PHYSIOLOGY

Author Affiliations

UTICA, N. Y.

Arch Ophthalmol. 1940;24(6):1123-1138. doi:10.1001/archopht.1940.00870060065004
Abstract

In a recent article1 I made the statement that "The basic pathology is identical for acute exudative choroiditis, acute spastic closure of the central retinal artery and acute retrobulbar neuritis. This process consists of arteriolar spasm, capillary dilatation and increased capillary permeability with transudation of plasma, white cells and, in severe cases, erythrocytes. . . . This picture will vary, depending on the anatomic structure of the involved tissue, but the differences seen from tissue to tissue and from lesion to lesion are quantitative rather than qualitative. The result is tissue anoxia."

It was pointed out that the factor determining the location of the lesion in the choroid, retina or optic nerve was probably an increased sensitivity of the smooth muscle in the arteriolar wall to some substance in the circulating blood. "The recurrence of similar lesions in the same person would seem to indicate that this vascular sensitivity is of fundamental

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