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February 1941


Author Affiliations

From the Department of Ophthalmology, Columbia University College of Physicians and Surgeons, and the Institute of Ophthalmology, Presbyterian Hospital.

Arch Ophthalmol. 1941;25(2):255-279. doi:10.1001/archopht.1941.00870080079006

LYMPHOGRANULOMA VENEREUM  Lymphogranuloma venereum has been defined by Stannus1—who called it the sixth venereal disease—as a human contagious disease which is acquired venereally, is possibly more common in warm climates than in cold and is due to an ultramicroscopic filtrable virus communicable to certain experimental animals. Although the genital tract is the usual portal of entry, extragenital infections have occurred, purposefully (Levaditi, Marie and Lépine2) and accidentally (Appelmans3). With the exception of these rare cases, the disease may be said to develop in three stages (Coutts4).

Stages of the Disease. 

—First Stage:  After an incubation period varying from a few days to two weeks, the initial lesion develops as a small, insignificant, often transitory, ulcerative or herpetiform inoculatory lesion on the genitalia.

Second Stage:  Ten days to several weeks or even months after the appearance of the initial lesion, a characteristic subacute or chronic inflammatory

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