Following the suggestion of Tulipan,1 I have treated 12 patients with nonulcerative blepharitis by applying brilliant green (tetraethyldiaminotriphenylmethane sulfate). Some of the lesions were associated with seborrheic dermatitis, acne or sycosis vulgaris, and others were of unknown causation. The duration was from two weeks to four years.
The solution was applied to the eyelids daily for several weeks with a small applicator so as not to stain the surrounding skin unnecessarily. No ill effects were noted from getting any of the solution on the conjunctiva, but care was taken not to do so. During this time the patients wore smoked glasses to avoid attracting undesired attention. The stain wore off a few days after treatment was discontinued. Adult patients averred that there was a "tingling sensation," but children, the youngest of whom was 12 years old, stated that they felt no pain. No other treatment was used for the
Franks AG. USE OF BRILLIANT GREEN IN TREATMENT OF BLEPHARITIS. Arch Ophthalmol. 1941;25(2):334–335. doi:10.1001/archopht.1941.00870080158014