Dysostosis multiplex was first reported by Hurler1 in 1919 but was given its present name by Binswanger and Ullrich2 in 1933. There are about 25 published cases. This rare form of dwarfism, usually discovered during the first year of life, is characterized by scaphocephalic or chondrodystrophic deformities of the skull and by chondrodystrophic changes in other parts of the skeleton. The head is large and the facial portion of the skull massive, with prominent frontal bosses. The root of the nose is broad and depressed. The alveolar processes are large and the tongue thick and fleshy. The neck is so short as to appear almost nonexistent. The trunk is short, the spine kyphotic and the abdomen protuberant. The liver and the spleen are enlarged. The limbs are short and plump, with limitation of movements of the joints. As a rule the mentality is impaired. In all the reported
VEASEY CA. OCULAR FINDINGS ASSOCIATED WITH DYSOSTOSIS MULTIPLEX AND MORQUIO'S DISEASE: REPORT OF A CASE OF THE FORMER. Arch Ophthalmol. 1941;25(4):557–563. doi:10.1001/archopht.1941.00870100035004
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