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Article
May 1941

CORRELATION OF THE RESULTS OF THE BIOPHOTOMETER TEST WITH THE VITAMIN A CONTENT OF HUMAN BLOOD

Author Affiliations

RALEIGH, N. C.; DURHAM, N. C.

Arch Ophthalmol. 1941;25(5):827-832. doi:10.1001/archopht.1941.00870110079008
Abstract

During the last fifteen years the work of many investigators has established a relation between some phases of visual acuity and the state of vitamin A nutrition in animals (for full bibliography see the articles by McCollum and his associates1 and Hecht2). Fridericia and Holm3 showed that night blindness is an early symptom of vitamin A deficiency. Wald4 demonstrated that vitamin A enters into the constitution of the visual purple, which constantly traverses a cycle of breakdown and resynthesis when light falls on the retina. In the absence of a fresh supply of vitamin A carried by the circulation the resynthesis is retarded and the visual threshold of the eye is raised; this is the change underlying the onset of some night blindness.

As a result of these findings it has seemed logical to explore the possibility that night blindness in man (when there is no

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