From the publication of the earliest description of sympathetic ophthalmia to the present day, many articles have been written on this interesting subject. With all the knowledge of the disease, the exact cause is still unknown. The vast majority of articles and case reports attribute the predisposition to the disease to trauma, usually the perforating variety. Little credence has been given to a nontraumatic origin.
In a recent article Irvine1 stated that "no record was found at the Massachusetts Eye and Ear Infirmary of sympathetic ophthalmia occurring without there having been operative or traumatic perforation of the globe prior to its onset." He further stated: "There are reports in the literature describing sympathetic uveitis in sarcomatous eyes without perforation. The rarity of these indicates that further confirmation of the absence of perforation or operative intervention is needed." This point is well made, as even a serial section of the
RIWCHUN MH, De COURSEY E. SYMPATHETIC OPHTHALMIA CAUSED BY NON-PERFORATING INTRAOCULAR SARCOMA. Arch Ophthalmol. 1941;25(5):848–858. doi:10.1001/archopht.1941.00870110102011