The use of the various vitamins in the treatment of ocular and neurologic diseases has led in some instances to satisfactory results. Because of the value of thiamine (vitamin B1) hydrochloride in the treatment of tobacco and alcohol amblyopia, as well as of certain forms of peripheral neuritis, it was reasonable to assume that this vitamin might have some effect on the process responsible for tryparsamide reactions. In 1939, Muncy1 reported 50 cases in which "vitamin B" (B1) and "B complex" were administered during the course of tryparsamide therapy, and from his study of these cases he gained the impression that yeast tablets are protective against tryparsamide amblyopia. He also reported the case of a patient in whom preexisting tryparsamide amblyopia was improved after administration of the yeast tablets.
To test this assumption further, we felt that it would be desirable to utilize thiamine hydrochloride in large
LEINFELDER PJ, STUMP RB. THIAMINE HYDROCHLORIDE IN THE TREATMENT OF TRYPARSAMIDE AMBLYOPIA. Arch Ophthalmol. 1941;26(4):613–618. doi:10.1001/archopht.1941.00870160089008
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