Zinc sulfate solutions in varying concentrations have been used in the practice of ophthalmology for many years. However, in spite of their long popularity as ophthalmic medicaments, almost all such solutions as ordinarily dispensed have two disadvantages. First, they are irritating to the delicate corneal tissues and, as a result, produce excessive lacrimation. This condition causes the active ingredients to be washed from the eye, thus greatly decreasing the therapeutic effectiveness of the zinc sulfate. Secondly, most of the preparations are dispensed unpreserved and contain zinc sulfate in combination with boric acid—a mixture which constitutes an admirable medium for the growth of microorganisms such as yeasts and molds.1
We have undertaken the present study in an effort to produce non-irritating and preserved zinc sulfate solutions which will lend themselves to more effective medication of the eyes than most such solutions now in common use. The adjustments made on ordinary
ARRIGONI L, FISCHER L, TOZER GA. OPHTHALMIC ZINC SULFATE SOLUTIONSBUFFERED, ISOTONIC AND PRESERVED. Arch Ophthalmol. 1941;26(5):852–858. doi:10.1001/archopht.1941.00870170144011
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