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Before sulfathiazole (2-[paraaminobenzenesulfonamido]-thiazole) or sulfanilamide is added to an ointment base, the powder should be sifted and a paste made with an equal amount of boiling water.
To 4 parts of sodium alginate add 75 parts of boiling water ; emulsify and strain, and then stir until cool. Add 16 parts of anhydrous wool fat, 78 parts of white petrolatum and 1 part of sodium chloride dissolved in 4 parts of water.Use a water bath to melt the first four ingredients and then add water, stirring constantly.Heat the first three items to 140 F. Add them to the water at the same temperature, stirring constantly.Base 1 is not irritating and is best for ophthalmic use, although the others may be used.
Elvin NC. PREPARATION OF SULFATHIAZOLE OR SULFANILAMIDE OINTMENT. Arch Ophthalmol. 1942;27(2):373–374. doi:10.1001/archopht.1942.00880020159017
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