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Article
April 1942

THE EYE IN ADRENAL SYMPATHICOBLASTOMA (NEUROBLASTOMA): IMPORTANCE OF OCULAR FINDINGS, WITH FIRST PATHOLOGIC REPORT OF METASTATIC TUMOR IN CHOROID

Author Affiliations

CHICAGO; Formerly Resident in Ophthalmology, University of Chicago Clinics MILWAUKEE
From the Division of Ophthalmology, Department of Surgery, the University of Chicago School of Medicine, E. V. L. Brown, Director.

Arch Ophthalmol. 1942;27(4):746-761. doi:10.1001/archopht.1942.00880040122012
Abstract

Adrenal sympathicoblastoma, or neuroblastoma, as it is commonly called, is a malignant tumor occurring almost exclusively in infants and children. Burch found that it does rarely occur in adults. The typical cell is an embryonal nerve cell derived from neural ectoderm and is the primary sympathetic cell. Bailey and Cushing used the term sympathicoblasts, applying it to a group of undifferentiated pluripotential cells derived from the ganglion crest. These migrate into the visceral areas to form a primordium of the sympathetic nervous system and finally differentiate into more mature forms, namely the unipolar and the multipolar neuroblasts. This tumor has the same embryonic origin as the medulla of the suprarenal gland and the adjacent sympathetic ganglions and may arise from either. Bailey and Cushing expressed preference for the term sympathicoblastoma because not all cells in the tumor are potentially neuroblasts. Some may differentiate into chromaffin cells. Sympathicoblastoma is a malignant

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