[Skip to Navigation]
August 1942


Author Affiliations

From the Department of Ophthalmology, Columbia University College of Physicians and Surgeons, and St. Luke's Hospital.

Arch Ophthalmol. 1942;28(2):205-213. doi:10.1001/archopht.1942.00880080023002

Experimentally, the bacteriostatic effectiveness of sulfathiazole (2-[paraaminobenzenesulfonamido]-thiazole) in vitro is equal to,1 and in many instances greater than,2 that of sulfanilamide and other derivatives against infections produced by such organisms as Staphylococcus aureus,3 Bacillus proteus,1a Streptococcus (hemolytic),4 Pneumococcus5 (types I, II and III)5 and Gonococcus.2a

It is reasonable to expect satisfactory clinical results in ophthalmology if an adequate concentration of the drug can be introduced into the ocular fluids and tissues. The experiments of Bellows and Chinn and others6 have shown that oral therapy is inadequate. As far as is known, the local application of sulfathiazole has not been investigated experimentally.7

The local application of other compounds of the group has met with limited experimental success. Except in the case of sulfanilamide, the concentrations obtained in the eye were too low to be of clinical value. Mengel7a obtained a

Add or change institution