The obscure condition of uveitis with poliosis, vitiligo, alopecia and dysacousia (known also as the Vogt-Koyanagi syndrome) is definitely accepted as a clinical entity. The disease is characterized by severe spontaneous bilateral uveitis accompanied by canities, white areas in the skin and falling of the hair and is often associated with disturbances of hearing. It has a protracted course, responds poorly to treatment and usually ends in partial or complete blindness.
The first case report was made by Vogt1 in 1906. He described the association of nontraumatic idiopathic uveitis with poliosis. His patient also had alopecia, though only brief mention was made of the fact. Vogt considered the conditions present as constituting one disease. In 1929 Koyanagi,2 after having observed 6 cases, published an article containing a full description of the disease and a table of 16 cases reported by him and other writers. Babel3