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Article
March 1943

EXPERIMENTAL STUDIES OF OCULAR TUBERCULOSIS: VII. EFFECT OF DESENSITIZATION WITH TUBERCULIN IN EXPERIMENTAL OCULAR TUBERCULOSIS

Author Affiliations

BALTIMORE
From the Wilmer Ophthalmological Institute of the Johns Hopkins University and Hospital.

Arch Ophthalmol. 1943;29(3):369-379. doi:10.1001/archopht.1943.00880150043002
Abstract

In previous papers of this series experiments were reported which revealed the following facts: 1. When normal rabbits are systemically inoculated with virulent human tubercle bacilli, there results a self-limited low grade tuberculosis which provides a relative resistance to reinfection and a definite tissue hypersensitivity to tuberculin. In these immuneallergic rabbits the ocular sensitivity parallels the general cutaneous sensitivity.1 2. When normal and immune-allergic rabbits are inoculated in the anterior chamber with tubercle bacilli or tuberculin, the degree of inflammation resulting parallels the degree of hypersensitivity to tuberculin present or developing in the inoculated eye. Thus, in a normal rabbit the reception of tubercle bacilli in the eye causes no immediate reaction. The bacilli grow freely in the eye, undeterred by any immunity, and a high degree of local sensitivity results. Coincident with the growth of the organisms and the development of local hypersensitivity, there is acute tuberculous inflammation

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