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Article
April 1943

ROLE OF ASCORBIC ACID (VITAMIN C) IN SECRETION OF INTRAOCULAR FLUID

Author Affiliations

BALTIMORE
From the Wilmer Ophthalmological Institute of the Johns Hopkins University and Hospital.

Arch Ophthalmol. 1943;29(4):535-574. doi:10.1001/archopht.1943.00880160025002
Abstract

OUTLINE 

  • Introduction

  • Redox substances in the ciliary body

    1. Titration and identification

      1. Technic

      2. Results

      3. Summary

    2. Location of redox substances in the tissues

      1. Ascorbic acid

      2. Glutathione

      3. Summary

  • Ascorbic acid in the mechanism of secretion of intraocular fluid

    1. Redox substances in the ocular tissues of guinea pigs

    2. Oxidation-reduction potential

    3. Irreciprocal permeability to dyes

    4. Transfer of water

  • Mechanism of storage of ascorbic acid

  • Intraocular secretion of ascorbic acid

  • Intraocular secretory systems without ascorbic acid

  • Comment

  • Summary

INTRODUCTION  In a previous paper1 certain components of the secretory mechanism in the ciliary body were described and a theory was formulated to explain their interaction. The present study is a continuation of the same investigation. Ascorbic acid (vitamin C) is a substance derived from the blood but present in the intraocular fluid in a concentration appreciably higher than in the blood.2 Energy must be expended by the tissues to maintain the difference in concentration. The

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