On rare occasions during the past five or six years an unusual type of corneal lesion has been seen in association with dermatitis of the eyelids and conjunctivitis. Suspicions were entertained that these conditions were allergic, but only recently has it been proved that they are due to contact with certain specific agents, such as drugs, cosmetics, foods and bacterial toxins.
Reference to the literature revealed relatively few reports of allergic keratoconjunctivitis. Among them were reports of keratitis parenchymatosa with urticaria, by Stern1; of peculiar subepithelial infiltrates which appeared after ingestion of antipyrine, by Sjögren2; corneal ulcers due to allergy to orris, by Parlato3 ; superficial keratitis with pollen allergy, by Manksch,4 and corneal destruction by contact with procaine hydrochloride and pontocaine hydrochloride, by Klar.5
Hypersensitivity of the tissues to certain specific agents is seen most frequently in the skin and mucous membranes ; however, it may
O'BRIEN CS, ALLEN JH. ALLERGIC KERATOCONJUNCTIVITIS. Arch Ophthalmol. 1943;29(4):600–604. doi:10.1001/archopht.1943.00880160090006
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