In 1913 Durand, Nicolas and Favre116 published the first comprehensive description of lymphogranuloma venereum, which had previously been confused with tuberculosis, syphilis and other diseases. In 1925 Frei117 described the intradermal test which bears his name, in which an antigen prepared by sterilizing pus from unruptured buboes of lymphogranuloma venereum produces in persons who have or who have had the disease a specific inflammatory reaction. In 1930 Hellerström and Wassen118 demonstrated that the causal agent is a filtrable virus.Lymphogranuloma venereum, also known as lymphogranuloma inguinale or lymphopathia venerea (um), is primarily a disease of the lymphatic system. In the male the principal lesion is inguinal adenitis ; in the female the characteristic lesions are elephantiasis of the external genitalia and chronic ulceration of the vulva, peritoneum, anus or rectum, leading to fistula and rectal stricture. A large number of extragenital manifestations have been described. Among
THYGESON MP. VIRUSES AND VIRUS DISEASES OF EYE: II. VIRUSES OF OCULAR IMPORTANCE. Arch Ophthalmol. 1943;29(4):635–661. doi:10.1001/archopht.1943.00880160125011
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