Repeated attempts were made to introduce the common mydriatics employed in ophthalmology by means of a galvanic current1 because an increased activity of these drugs is desirable in a number of pathologic conditions of the eye. Rochatla studied the iontophoretic administration of atropine and other alkaloids in experiments on rabbits and by clinical observation. When other clinical methods had failed, he demonstrated the effectiveness of the iontophoretic method in breaking resistant posterior synechias despite the low concentration of the atropine sulfate solution (0.1 per cent). Rochat based his conclusions on measurements of the pupils of treated eyes. He did not consider, however, the effect of electric current per se, which increases or decreases the size of the pupil in different degrees according to the strength of the current and the length and method of application. Quantitative determinations of the mydriatics found in different parts of the eye after
VON SALLMANN L. IONTOPHORETIC INTRODUCTION OF ATROPINE AND SCOPOLAMINE INTO THE RABBIT EYE. Arch Ophthalmol. 1943;29(5):711–719. doi:10.1001/archopht.1943.00880170027002
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