In 1938 I 1 reported on precancerous melanosis of the conjunctiva and skin of the lids and on the type of malignant melanoma (cancerous melanosis) to which this melanosis gives rise. The purpose of the present report is to record further observations on these acquired conditions and to discuss their relationship to the congenital nevus and the malignant melanoma which may arise from it.
Precancerous melanosis is a diffuse, nonelevated pigmentation which has a granular appearance, with sometimes a slight loss of luster of the involved conjunctival surface. The average age at which it appears is from 40 to 50 years, and the average length of time between its appearance and the malignant change is from five to ten years. The interval may be a great deal longer or considerably shorter, however, and at times the melanosis is malignant from the beginning. An important characteristic is its diffuseness. The lesion
REESE AB. PRECANCEROUS MELANOSIS AND THE RESULTING MALIGNANT MELANOMA (CANCEROUS MELANOSIS) OF CONJUNCTIVA AND SKIN OF LIDS. Arch Ophthalmol. 1943;29(5):737–746. doi:10.1001/archopht.1943.00880170055004
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