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May 1943


Arch Ophthalmol. 1943;29(5):747-759. doi:10.1001/archopht.1943.00880170067005

In a series of papers that have been published in recent years Duggan1 has projected a conception of ocular pathology predicated on vascular dysfunction. It is based both on physiologic and on clinical observation, and its validity has apparently been established by successful therapeutic practice. Primarily Duggan stressed the pathologic significance of vascular spasm, both in precipitating the clinical episode and in initiating the primary dysfunction. Such spasm, transient or prolonged, localized or occurring as part of a more general increase in vascular fine, brings in its train a series of local disturbances in water balance, [ill] cellular permeability, in ion balance (pH, potassium/calcium, chlorides, phosphates), etc., with resulting clinical phenomena that may take various forms.

Duggan has called attention to the precipitation of the acute episode with chilling or with change in the weather, though obviously other factors may be effective in the vascular balance, for example allergic,