There are now numerous reports in the literature describing good results from the direct application of the sulfonamide compounds in the prophylaxis and treatment of wound infections1 and in the treatment of pyogenic cutaneous infections.2 There are a lesser number of reports describing direct treatment with sulfonamide compounds of infections of the mucous membrane, particularly of the mouth, nose and throat,3 but also of the eye4 and the female genitourinary tract. In this connection, the field of external ocular infections has been incompletely explored, and at the time of writing no study of the effect of topical application in catarrhal conjunctivitis has appeared. The present study reports the results obtained in 512 cases of acute and chronic catarrhal conjunctivitis with sulfathiazole (2-[paraaminobenzenesulfonamido]-thiazole) and sulfadiazine (2-[paraaminobenezenesulfonamido]pyrimidine) applied in ointment form.
METHOD OF TREATMENT
The sulfonamide compounds have been used locally in solution, powder, emulsion and ointment forms.
THYGESON P, BRALEY AE. LOCAL THERAPY OF CATARRHAL CONJUNCTIVITIS WITH SULFONAMIDE COMPOUNDS. Arch Ophthalmol. 1943;29(5):760–766. doi:10.1001/archopht.1943.00880170080006
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