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Article
May 1943

DEGENERATION AND REPAIR OF THE RAT RETINA IN AVITAMINOSIS A

Author Affiliations

NORTHAMPTON, MASS.
Knapp Fellow in Ophthalmology, Columbia University College of Physicians and Surgeons.

Arch Ophthalmol. 1943;29(5):793-810. doi:10.1001/archopht.1943.00880170113011
Abstract

Although night blindness and various other ocular disturbances have for centuries been associated with a dietary deficiency of the body, it is only within recent years, through the work of Fridericia and Holm,1 Tansley2 and others, that vitamin A deficiency has been identified as the specific cause of these visual defects. Still more recently the investigations of Wald3 have revealed that vitamin A is directly concerned with the visual process in that it is the precursor of visual purple as well as a product of its decomposition. It has been shown also, in experimental studies, that adult human subjects (Wald, Jehgers and Arminio,4 Wald and Steven,5 Booher, Callison and Hewston6 and Steven and Wald7) and infants (Lewis and Haig8) kept on a diet low in vitamin A until a certain degree of night blindness was exhibited recovered normal vision with startling rapidity

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