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May 1943


Author Affiliations

From the Department of Ophthalmology, University of Pennsylvania School of Medicine.

Arch Ophthalmol. 1943;29(5):811-817. doi:10.1001/archopht.1943.00880170131012

Recently a new form of the sulfonamide compounds was developed. This is the microcrystalline form produced by either sonic vibration or use of some rapid mixing device.1 The chief difference from the ordinary sulfonamide compounds is the smaller size of the crystals, which renders more surface available and also permits passage through a 26 gage needle of concentrations as high as 20 per cent.

Studies were undertaken in an attempt to evaluate this new physical property in ophthalmology. In a recent article2 we showed that the ratio between the concentrations of sulfathiazole (2-[paraaminobenzenesulfonamido]-thiazole) in the aqueous and in the blood of cats with approximately the same with intraperitoneal injection of microcrystalline and oral administration of macrocrystalline sulfathiazole.

Both Guyton3 and Chinn and Bellows4 have demonstrated the relatively greater penetration of sulfanilamide than of its derivatives when applied locally. They showed that sulfathiazole penetrated into the aqueous

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