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Article
July 1943

LOCAL TOXIC EFFECTS OF SULFANILAMIDE AND SOME OF ITS DERIVATIVES

Author Affiliations

With the Laboratory Assistance of Robert Gluckman, B.S. CHICAGO
From the Department of Ophthalmology, Northwestern University Medical School.

Arch Ophthalmol. 1943;30(1):65-69. doi:10.1001/archopht.1943.00880190083007
Abstract

Since the topical application of the sulfonamide compounds is gaining widespread use in many branches of surgery, it is imperative that knowledge of the local tissue reaction to these drugs, which is meager and of controversial nature, be increased. The chemotherapeutic effectiveness of the drugs is too well established to require either discussion or review of the literature in this report.

The in vitro studies of Jacoby and associates1 revealed that sulfanilamide, sulfathiazole (2-[paraaminobenzenesulfonamido]-thiazole), sulfapyridine (2-[paraaminobenzenesulfonamido]-pyridine) and sulfadiazine (2-[paraaminobenzenesulfonamido]-pyrimidine) produce unfavorable morphologic effects and inhibition of growth in living fibroblasts, macrophages and epithelial cells. These authors found that in equal concentrations sulfathiazole is the most toxic, but stated that under clinical conditions the toxicity depends on the solubility of the drugs. They are soluble in descending order as follows : sulfanilamide, sulfathiazole, sulfapyridine and sulfadiazine. Bellows and Chinn2 found that a moderate reaction, indicated by chemosis and epithelial staining,

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