In 1937 Myerson and Thau,1 in Boston, suggested that benzedrine sulfate might be useful in producing cycloplegia, since it produces excellent mydriatic action. Accepting this suggestion, Beach and McAdams,2 in Maine, set up a study of benzedrine sulfate and combined this drug with 1 per cent atropine sulfate solution and also 5 per cent homatropine hydrobromide solution. In a small number of cases these combinations were used as cycloplegics, and the authors concluded that the time required to obtain cycloplegia was decreased, while the recovery time for the patient was considerably reduced. In general about forty to sixty minutes was required for complete cycloplegia when atropine sulfate solution followed by benzedrine sulfate solution was employed.
The work of Beach and McAdams was confirmed by Powell and Hyde,3 who in two articles reported good results from 2 per cent homatropine solution with 1 per cent benzedrine sulfate solution.
YASUNA E. HOMATROPINE-PAREDRINE EMULSION AS A CYCLOPLEGIC. Arch Ophthalmol. 1943;30(1):87–92. doi:10.1001/archopht.1943.00880190105010
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