We began an investigation in 1939 into the histopathology of malignant melanoma of the uvea of patients treated at the Glasgow Eye Infirmary during the preceding twenty years. Callender and Wilder1 and King2 had published papers in which it appeared that the prognosis was influenced by the reticulin content of the growths. They had observed their patients for five years or over. Pahwa3 reported on a series of 100 patients observed for six years and found the reticulin content to be a helpful guide in prognosis. Callender, Wilder and Asch4 have reported on a series of 500 patients observed over five years, and of that number 200 have been observed for ten years. Our investigation was interrupted by the outbreak of war, but we felt that the study of a series of patients for a long period, namely twenty years, would give further information. There were
McGREGOR IS, HILL J. RETICULIN CONTENT AND PROGNOSIS IN MALIGNANT MELANOMA OF THE UVEA. Arch Ophthalmol. 1943;30(3):291–297. doi:10.1001/archopht.1943.00880210015001
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