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Article
October 1943

PENICILLIN AND SULFADIAZINE: IN THE TREATMENT OF EXPERIMENTAL INTRAOCULAR INFECTION WITH PNEUMOCOCCUS

Author Affiliations

NEW YORK
From the Department of Ophthalmology of Columbia University College of Physicians and Surgeons and the Institute of Ophthalmology of Presbyterian Hospital.

Arch Ophthalmol. 1943;30(4):426-436. doi:10.1001/archopht.1943.00880220018002
Abstract

Diplococcus pneumoniae is considered the most frequent cause of severe intraocular infections following perforating injuries. Morax and Moreau,1 A. von Szily2 and K. Lindner3 stressed the importance of this organism in infections of penetrating wounds of the eye in modern warfare. Therefore the chemotherapy of experimental post-traumatic endophthalmitis caused by the pneumococcus was selected for the present study, which is the first part of more extensive investigations on the treatment of intraocular infections.

Statistical data on the types of pneumococci in cases of endophthalmitis and panophthalmitis following various perforating injuries are not available. Only in a few such cases have the types been identified according to Cooper's classification. It is justifiable, however, to apply to intraocular infections the statistical figures of the incidence of the various pneumococcic types present on the normal conjunctiva and isolated in external diseases of the eye, because it is assumed that the

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