Physostigmine, because of its potent parasympathomimetic action, has retained an important position in ophthalmic therapy since first used as a miotic by Laqueur (1876).1 It is administered usually in an aqueous solution and less frequently in an ointment or lamella. The official preparation is physostigmine salicylate, although the sulfate, which possesses similar pharmacologic properties, is also available.
This paper presents a comparison of the effectiveness of the various methods of local application, including iontophoresis and the use of a wetting agent. new method, its relative advantages and disadvantages must be carefully balanced. As part of the evaluation it is desirable to know the amount of drug entering the eye. Therefore a quantitative estimation was made of the physostigmine content of the aqueous humor of the rabbit's eye with different methods of application. No local or general deleterious effects were noted with any of the procedures described. A temporary corneal
BOYD JL. QUANTITATIVE COMPARISON OF METHODS OF ADMINISTERING PHYSOSTIGMINE. Arch Ophthalmol. 1943;30(4):521–525. doi:10.1001/archopht.1943.00880220113011
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