Carbaminoylcholine chloride is a synthetic drug introduced in 1932 as a longacting substitute for acetylcholine. The drug produces miosis and cyclotonia and decreases intraocular pressure ; consequently, it is used as an agent in the treatment of glaucoma. Carbaminoylcholine chloride is poorly absorbed from the conjunctival sac when instilled in simple aqueous solutions ; however, O'Brien and Swan1 found that when precautions were taken to insure absorption, carbaminoylcholine chloride had a more intense and prolonged hypotensive effect on glaucomatous eyes than had corresponding doses of pilocarpine salts. They observed that the addition of a surface tension-reducing agent, zephiran chloride, facilitated penetration of carbaminoylcholine chloride from aqueous solutions into the normal cornea. However, other precautions are necessary to insure absorption. The solution of the drug must be administered so that it covers the cornea, and the lids must be kept closed to maintain good contact between the cornea and the solution for
SWAN KC. CARBAMINOYLCHOLINE CHLORIDE IN PETROLATUM. Arch Ophthalmol. 1943;30(5):591–592. doi:10.1001/archopht.1943.00880230023002
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