Prior to the use of sulfanilamide and its derivatives, infectious thrombosis of the cavernous sinus was usually fatal. MacNeal, Frisbee and Blevins1 recently collected 58 cases in which the patients recovered. In 17 of these cases the thrombosis was of staphylococcic origin. In 4 cases recovery followed expectant treatment ; in 2 cases, prophylactic surgical measures; in 1 case, early radical operation; in 4 cases, bacteriophage therapy, and in 1 case, the use of antitoxin, while in the remaining 5 cases cure was obtained with various sulfonamide compounds. In a later report2 the same authors published the results in 45 cases of thrombosis of the cavernous sinus of staphylococcic origin in which only bacteriophage therapy was given. In 14 cases the patients survived; in 23 cases they died within five days, and in 8 cases they died after a prolonged illness.
In 1941 Schall3 reported 3 cases in