Clinical research and practical observation at times may call the attention of members of the medical profession to deviations from the normal without providing an insight into the basic physiologic and pathologic changes. This report serves such a function. It lacks a bibliography, a history of the use of diethylstilbestrol or a discussion of the phenomenon of accommodation. Since I have seen accommodative changes in cases in which diethylstilbestrol has been used for several years and have found no previous report of such a case in the literature, it seemed wise to record representative cases for the enlightenment of ophthalmologists and endocrinologists.
Since the advent of the use of diethylstilbestrol or similar androgens for the relief of symptoms of sexual dysfunction in females, or more usually of disturbances of the menopause, I have examined about 40 women with complaints which, when analyzed, were found to be due to difficulties in