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November 1944


Author Affiliations

Passed Assistant Surgeon (R), United States Public Health Service; Surgeon, United States Public Health Service; Passed Assistant Surgeon (Division of Pathology), United States Public Health Service; Junior Chemist, United States Public Health Service BETHESDA, MD.
From the Industrial Hygiene Research Laboratory, National Institute of Health, United States Public Health Service.

Arch Ophthalmol. 1944;32(5):391-394. doi:10.1001/archopht.1944.00890110059007

For the past year and a half studies have been carried out in this laboratory on the toxicity of 1,2-dichloroethane (CH2Cl-CH2Cl). It was found that guinea pigs, mice, rats and rabbits were killed by only a few exposures of seven hours each to the vapor in concentrations as low as 400 parts per million. Dogs remained in good condition after nearly 200 exposures to a concentration of 400 parts per million, but with a concentration of 1,000 parts per million some of the animals died. The investigation is still in progress. This paper is concerned with one phase of the toxicity of dichloroethane, namely, its peculiar action on the cornea of certain species of animals.

A number of authors have observed that the eyes of dogs became cloudy after inhalation narcosis with dichloroethane.1 This report presents observations on the corneal reaction to single and to

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