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Article
September 1945

CAVERNOUS DEGENERATION, NECROSIS AND OTHER REGRESSIVE PROCESSES IN OPTIC NERVE WITH VASCULAR DISEASE OF EYE

Author Affiliations

GLASGOW, SCOTLAND
From the Tennent Institute of Ophthalmology, Glasgow University (Prof. W. J. B. Riddell).

Arch Ophthalmol. 1945;34(3):220-226. doi:10.1001/archopht.1945.00890190220008
Abstract

Schnabel discovered cavernous degeneration in the tissue of the optic nerve in glaucomatous eyes. He1 and his pupil Elschnig2 declared that the condition was peculiar to glaucoma. Other investigators, like Axenfeld and Stock,3 found cavernous changes in the nerve in cases of high myopia. Koyanagi and Takahashi4 and other authors observed the condition in eyes excised for intraorbital tumor. Lagrange and Beauvieux5 demonstrated pronounced vascular changes in glaucomatous eyes which showed cavernous degeneration of the nerve. In several cases of primary glaucoma they discovered sclerosis and obliteration of the laminar and retrolaminar vascular twigs in the optic nerve. It is interesting that they correlated cavernous degeneration of the optic nerve with similar features described in brain tissue in association with vascular disease, called by Pierre Marie état lacunaire and by C. and O. Vogt état criblé. It is likewise interesting that Duke-Elder6 stated that

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