Waksman and his associates have isolated two apparently related substances, streptothricin1 and streptomycin,2 from the genus Streptomyces which are more bacteriostatic or bactericidal for gram-negative bacilli than is penicillin. Of the two, streptomycin has been shown to be less toxic and to possess greater action against certain gram-negative and gram-positive bacteria in vivo3. Streptomycin has been demonstrated to be beneficial in treatment of experimental infections due to Proteus vulgaris4, Pasteurella tularenis,5 Mycobacterium tuberculosis6 and organisms of the Friedländer group7 in animals. Recently streptomycin was shown to have possible benefit in cases of typhoid infection in man.8
Zintel and his co-workers9 have shown that the concentration of streptomycin in the blood following a single intravenous injection is better maintained than that of penicillin. Detectable amounts were usually present six hours after intramuscular administration, as compared with two to three hours in the
LEOPOLD IH, NICHOLS A. INTRAOCULAR PENETRATION OF STREPTOMYCIN FOLLOWING SYSTEMIC AND LOCAL ADMINISTRATION. Arch Ophthalmol. 1946;35(1):33–38. doi:10.1001/archopht.1946.00890200037007
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