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March 1946

KERATOCONJUNCTIVITIS SICCA AND BUCCOGLOSSOPHARYNGITIS SICCA WITH ENLARGEMENT OF PAROTID GLANDSReport of Two Cases of Sjögren's Syndrome, with Pathologic Study of a Lacrimal Gland and the Parotid Glands in One Case

Arch Ophthalmol. 1946;35(3):227-240. doi:10.1001/archopht.1946.00890200233003

SJÖGREN,1 in 1933, described a chronic disorder characterized by reduction in the secretions of the lacrimal and salivary glands with accompanying keratoconjunctivitis sicca, together with dryness of the mucous membranes of the mouth and the upper respiratory system. A persistent enlargement of the parotid glands sometimes occurs. The several publications of Sjögren on this subject have established the condition as a syndrome, now bearing his name. For a detailed description of the disease, reference should be made to the publication by Bruce,2 who in 1941 reviewed the literature on keratoconjunctivitis sicca and described additional cases.

In 1943 Gifford, Puntenney and Bellows3 classified cases with evidence of deficient lacrimation into three groups. In group I there was lacrimal deficiency, with moistening of less than 15 mm. in the Schirmer filter paper test after five minutes but with no corneal or associated changes. In group II there was fairly complete