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March 1946


Arch Ophthalmol. 1946;35(3):304. doi:10.1001/archopht.1946.00890200310012

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To the Editor:  —Dr. Kenneth L. Roper's paper entitled "Senile Hyaline Scleral Plaques" (Arch. Ophth.34:283 [Oct.] 1945) has enhanced the meager knowledge of diseases of the sclera. Unfortunately, in his section on differential diagnosis no mention is made of ochronosis.I observed a 78 year old man with bilateral "mesial" plaques while preparing my paper on "Ochronosis of the Sclera and Cornea" (Tr. Sect. Ophth., A.M.A., 1942, pp. 66-96). The site and color of the two conditions are similar ; in fact, Dr. Roper's colored plate shows the slate blue of the ochronotic patch better than does the slate purple in my drawings. Younger ophthalmologists viewing our illustrations would have difficulty in distinguishing the two diseases. The association, however, of alkaptonuria, osteoarthritis and pigmentation of the ears and scleras establishes the diagnosis of ochronosis.1016 Fifth Avenue (28).

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