TUMORS of the hematopoietic system of the conjunctiva are lymphomas, representing an extensive hyperplasia of the lymphoid tissue, either with or without constitutional disease. Tumors of the first type, associated with constitutional disease, are usually unilateral; those of the second type are bilateral and often symmetric. The changes are so well known that it would be pointless to recapitulate the literature. In a second group, the lymphosarcomas, there is evident malignancy; they are clinically soft, rapidly growing tumors and tend to spread through the lymphatics. The histologic appearance approaches that of the benign lymphomas, consisting of small round cells, with occasional larger reticulum cells.
A perusal of the literature dealing with involvement of the lymphatic system shows that as far back as a hundred years ago Hodgkin described a condition affecting the lymph nodes and the spleen. Numerous later investigators delimited distinct entities, such as leukemia and aleukemic leukemia,
RADOS A. RETICULUM CELL SARCOMA OF THE CONJUNCTIVA. Arch Ophthalmol. 1946;35(4):400–414. doi:10.1001/archopht.1946.00890200407007
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